Studies towards the synthesis of halomon: asymmetric hexafunctionalisation of myrcene.
Chem Commun (Camb)
; 50(89): 13725-8, 2014 Nov 18.
Article
in En
| MEDLINE
| ID: mdl-25249474
ABSTRACT
A novel dihydroxylation-dibromination-dihydroxylation sequence employing in situ protection of diols as boronate esters during the dihydroxylation reactions provides the first enantiomerically pure hexafunctionalised myrcene derivative. This concise four-step asymmetric sequence provides an advanced intermediate for the targeted synthesis of halomon via stereospecific transformations, where both stereogenic centres of the natural product have been set.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Monoterpenes
/
Alkenes
/
Hydrocarbons, Halogenated
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2014
Document type:
Article
Affiliation country: